電影中，霸氣的葉問一人單挑十人🥊成為經典畫面。
現在對抗流感也可望「一打多」！過去預防流感最佳方法是接種疫苗，但疫苗通常只針對單一亞型，一旦病毒突變，當年趕製的疫苗就會失去預期保護力。因此開發 #廣效型疫苗 是目前研究的目標之一。
本院翁啟惠院士領導的基因體研究中心團隊近期擷取兩種不同病毒株的蛋白質，組合成全新的血凝集素，再輔以本院獨創的 #單醣化技術，研發出 「單醣化嵌合血凝集素（chimeric HA）蛋白疫苗」。
實驗證實，此疫苗可「一打多」，能有效抵抗四種不同的H1N1病毒和兩種不同的H5N1病毒，達到至少80%的保護效果，甚至也能中和H3、H5、H7和H9等不同亞型的病毒，減少因誤判病毒株導致疫苗防護力不足的問題。
#翁啟惠 #疫苗 #A型流感 #廣效疫苗 #葉問 #一打十 #一打多
🥊怎麼做到一打多? https://www.sinica.edu.tw/ch/news/6614
🥊論文連結：https://www.pnas.org/content/early/2020/07/14/2004783117
圖片來源／電影《葉問》
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Professor Chi-Huey Wong had previously led a group thinking from outside of the box and created a mono-glycan H1N1 flu vaccine that proved effective against multiple flu subtypes. They have outdone themselves again, and this time, they came up with a breakthrough development of a universal anti-influenza vaccine using a designed chimeric hemagglutinin (HA) protein. The resulting immune responses in animal model showed coverages not only on various human influenza strains and subtypes, but also the emerging avian flu. They have published the result online in PNAS on July 15th.
#vaccine # influenza #PNAS #chimerichemagglutininprotein
🥊The article can be read online at:
https://www.pnas.org/content/early/2020/07/14/2004783117
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